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Scientific research

The Department of Neurology at Amsterdam UMC has a rich history in researching neurological infectious diseases. In recent years, the group has significantly expanded after receiving national and European grants. The current research lines include bacterial meningitis (MeninGene and SMS MeninGene studies), suspected infectious meningitis or encephalitis in children and adults (I-PACE and I-PACE Kids studies), neonatal meningitis (NOGBS study), and oral antibiotics for brain abscesses (ORAL study). Since 2025, research towards spontaneous intracranial hypotension has commenced (LEAK biobank). Other areas of our scientific interest include infections in patients with cerebrospinal fluid drains, the immunological response after a stroke, and the role of autoantibodies in meningitis and encephalitis.

If you are interested in conducting research with us or have a clinical question that might be answered using our database, please feel free to contact us.

 

Summaries of our ongoing clinical studies:

MeninGene & SMS

Bacterial meningitis is a severe infection of the meninges, which, despite prompt treatment, results in death or residual symptoms in a significant portion of patients.

Read more about MeninGene & SMS

I-PACE

The aim of the study is to develop new diagnostic tests to quickly establish the correct diagnosis in adult patients with meningitis and encephalitis.

Read more about I-PACE

I-PACE Kids

The aim of the study is to develop new diagnostic tests to quickly establish the correct diagnosis in pediatric patients with meningitis and encephalitis.

Read more about I-PACE Kids

NOGBS

The aim of the study is to prevent meningitis and sepsis in newborns by understand and predict early onset infections.

Read more about NOGBS

LEAK biobank

The aim of this biobank is to establish a cohort study for future research regarding spontaneous intracranial hypotension.

Read more about LEAK biobank